Thermo Fisher Scientific Human TLR1 Synthetic Peptide

Thermo Fisher Scientific Human TLR1 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 16 amino acids near the amino terminus of human TLR1.
PEP-0296 can be used as a blocking peptide with polyclonal antibody PA5-20181.

Target Information

TLR1 protein is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity.
TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) expressed on infectious agents and mediate cytokine production necessary for effective immunity.

The mammalian TLR family consists of transmembrane proteins characterized by multiple leucine-rich repeats in the extracellular domain and an IL-1 receptor motif in the cytoplasmic domain.
TLR1 interacts with TLR2 in mice, and co-expression enhances NF-kappaB activation in response to synthetic lipopeptides. They recognize the lipid configuration of native mycobacterial lipoproteins and several tri-acylated lipopeptides.
Different length transcripts may result from alternative polyadenylation sites or splicing events in the TLR1 gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.