Thermo Fisher Scientific GPR26 Monoclonal Antibody (OTI3D10), TrueMAB

Applications

• Western Blot (WB)
  Tested Dilution: 1:500

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).

Target Information

The G-protein-coupled receptor (GPCR) superfamily consists of approximately 600–1,000 members and represents the largest known class of molecular targets with therapeutic relevance.
GPR26 is a brain-specific orphan GPCR with constitutive activity mediated by G(s)-alpha protein, which stimulates adenylate cyclase and elevates intracellular cAMP levels.
Highest expression is found in the amygdala, hippocampus, and thalamus, with weak expression in testis.
GPR26 is down-regulated in glioblastoma, and its depletion increases fat storage in C. elegans. In mice, hypothalamic GPR26 deficiency is linked to genetic susceptibility to obesity and associated metabolic disorders such as glucose intolerance, hyperinsulinemia, and dyslipidemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.