Thermo Fisher Scientific CD209/DC-SIGN (Pathogen Receptor on Dendritic Cells) Monoclonal Antibody (rC209/1781)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: Assay-dependent

Immunohistochemistry (PFA fixed) (IHC (PFA))

• Tested Dilution: 1–2 µg/mL

Product Specifications

Target Information

This gene encodes a transmembrane receptor known as DC-SIGN, expressed on the surface of dendritic cells and macrophages. It plays a critical role in the innate immune system by recognizing diverse pathogens, including parasites and viruses.
The protein consists of three domains: an N-terminal transmembrane domain, a tandem-repeat neck domain, and a C-type lectin carbohydrate recognition domain.
The extracellular region mediates both pathogen recognition and cell adhesion through carbohydrate ligand binding. The neck region enables homo-oligomerization, allowing multivalent ligand binding with high avidity.
Variations in the neck domain repeats can affect ligand-binding capacity. DC-SIGN is closely related to L-SIGN (GeneID 10332) but differs in ligand specificity and tissue distribution.
Alternative splicing produces multiple isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.