Thermo Fisher Scientific ARC Polyclonal Antibody
ARC 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western Blot 및 Immunohistochemistry에 적합. 인간 ARC 유래 합성 펩타이드 면역원 사용. 액상 형태, 1 mg/mL 농도, -20°C 보관. 세포 사멸 억제 관련 연구용으로 적합.
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- PA538097
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Thermo Fisher Scientific ARC Polyclonal Antibody
Applications and Tested Dilutions
- Western Blot (WB): 1:500–1:1,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from human ARC |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554700 |
Target Information
ARC (also known as NOL3 - Nucleolar protein 3) has two isoforms.
Isoform 1 is involved in RNA splicing. Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death.
ARC inhibits extrinsic apoptotic pathways in two different ways:
- By interacting with FAS and FADD upon FAS activation, blocking death-inducing signaling complex (DISC) assembly.
- By interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting soluble CASP8 available for DISC-mediated activation.
ARC also inhibits intrinsic apoptotic pathways in response to a wide range of stresses through interactions with BAX, resulting in BAX inactivation and prevention of mitochondrial dysfunction and release of pro-apoptotic factors.
Mutations affecting the gene can result in myoclonus, familial cortical disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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