Thermo Fisher Scientific Caspase 1 (Cleaved Asp210) Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:100

Product Specifications

Target Information

Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation, and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a tetramer to form the active enzyme. Caspase-1/ICE (IL-1β converting enzyme) is similar to the cell death gene CED-3 of Caenorhabditis elegans and regulates multiple proinflammatory cytokines, including interleukin-1β and interferon-gamma-inducing factor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.