Thermo Fisher Scientific SUMO 4 Polyclonal Antibody
Rabbit polyclonal antibody against human SUMO4 protein. Suitable for Western blot and IHC applications. Lyophilized form with no preservative, reconstitute in sterile water. For research use only, not for diagnostic or resale purposes.
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Applications
Western Blot (WB)
- Tested Dilution: 1:300–1:2,000
- Publications: View 2 publications
Immunohistochemistry (IHC)
- Tested Dilution: 1:300–1:2,000
- Publications: View 2 publications
Miscellaneous (PubMed)
- Publications: View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the N-terminal of human SUMO4 (Small ubiquitin-related modifier 4) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: SUMO4.
Target Information
SUMO4 is a member of the SUMO gene family, which encodes small ubiquitin-related modifiers that covalently modify target lysines in proteins. These modifications regulate subcellular localization, stability, and activity of target proteins.
Upon oxidative stress, SUMO4 conjugates to various antioxidant enzymes, chaperones, and stress defense proteins. It may conjugate to NFKBIA, TFAP2A, and FOS (negatively regulating transcriptional activity), and to NR3C1 (positively regulating transcriptional activity).
SUMO4 attachment requires activation by the E1 complex (SAE1-SAE2) and linkage to the E2 enzyme (UBE2I). Unlike SUMO1–3, SUMO4 is insensitive to sentrin-specific proteases due to Pro-90, which may impair processing and conjugation.
SUMO4 is located in the cytoplasm and modifies IKBA, leading to negative regulation of NF-κB-dependent transcription of the IL12B gene. The M55V substitution has been associated with type I diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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