Thermo Fisher Scientific SHANK3 Polyclonal Antibody
SHANK3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC에 사용 가능하며, 인간·마우스·랫트 반응성. Lyophilized 형태로 제공되며 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 10–50 µg/mL |
| Immunohistochemistry (IHC) | 10–50 µg/mL |
| Miscellaneous PubMed (Misc) | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from human SHANK3 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: SHANK3.
Target Information
SHANK3 is a major scaffold postsynaptic density protein that interacts with multiple proteins and complexes to orchestrate dendritic spine and synapse formation, maturation, and maintenance. It connects receptors of the postsynaptic membrane, including NMDA-type and metabotropic glutamate receptors, via complexes with GKAP/PSD-95 and HOMER, and links them to the actin-based cytoskeleton.
SHANK3 contributes to dendritic spine structural organization through interactions with Arp2/3 and WAVE1 complexes and promotes F-actin clustering. By regulating actin dynamics, SHANK3 influences neuronal growth cone motility and NMDA receptor signaling. It also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling, controlling AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity.
SHANK3 may be required at early synapse formation stages and can be inhibited by IGF1 to promote synapse maturation. (Uniprot)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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