Thermo Fisher Scientific CD33 Monoclonal Antibody (OTI1E10), TrueMAB
인간 CD33 단백질을 인식하는 Mouse IgG1 단클론 항체로, ELISA 및 Luminex 분석에 적합합니다. 친화 크로마토그래피로 정제되었으며, 0.5 mg/mL 농도의 액상 형태로 제공됩니다. CD33 발현 세포 연구 및 급성 골수성 백혈병 관련 연구에 활용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| ELISA (ELISA) | 1:100–1:1,000 |
| Luminex (LUM) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E10 |
| Immunogen | Full length human recombinant protein of human CD33 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with <5% trehalose |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Available Formats:
Target Information
CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules capable of recruiting protein tyrosine phosphatases SHP-1 and SHP-2. These motifs also mediate ubiquitin-dependent removal of the receptor from the cell surface.
CD33 is expressed on cells of myelomonocytic lineage and binds sialic acid residues in N- and O-glycans on cell surfaces. It is a therapeutic target for acute myeloid leukemia and is found on granulocyte and macrophage precursors in the bone marrow, but not on pluripotent stem cells. CD33 is also expressed on peripheral monocytes and serves as a useful marker to distinguish myelogenous leukemia from lymphoid or erythroid leukemias. Diseases associated with CD33 dysfunction include gallbladder lymphoma and extracutaneous mastocytoma.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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