Thermo Fisher Scientific CD33 Monoclonal Antibody (OTI1E4), TrueMAB
인간 CD33 단백질을 인식하는 마우스 단클론 항체로, ELISA 및 Luminex 분석에 적합합니다. 고순도 친화 크로마토그래피 정제 제품이며, PBS 완충액에 보존되어 있습니다. CD33 관련 백혈병 연구 및 면역표지용으로 활용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| ELISA (ELISA) | 1:100–1:1,000 |
| Luminex (LUM) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E4 |
| Immunogen | Full-length human recombinant CD33 protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with <5% trehalose |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules capable of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies. These ITIMs are also involved in ubiquitin-mediated removal of the receptor from the cell surface.
CD33 is expressed on cells of the myelomonocytic lineage and binds sialic acid residues in N- and O-glycans on cell surfaces. It serves as a therapeutic target for acute myeloid leukemia. CD33 is present on granulocyte and macrophage precursors in bone marrow but not on pluripotent stem cells. It is also expressed on peripheral monocytes and is used as a marker for distinguishing myelogenous leukemia cells from lymphoid or erythroid leukemias.
Diseases associated with CD33 dysfunction include gallbladder lymphoma and extracutaneous mastocytoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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