Thermo Fisher Scientific PIGR Monoclonal Antibody (7C1)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This product was used in an Indirect ELISA.

Target Information

Polymeric IgA and IgM are produced and secreted by B cells in the lamina propria, located beneath the mucosal lining of polarized epithelial cells. Polymeric immunoglobulin receptors (pIgRs) are expressed on the basolateral surface of glandular epithelia and mediate transcellular transport of secretory immunoglobulin polymers across the epithelium.

pIgR associates with secreted dimeric IgA and IgM molecules. During transcellular transport, pIgR undergoes proteolytic cleavage to generate a fragment called secretory component (SC), also known as polymeric immunoglobulin receptor or poly-IG receptor. When immunoglobulin polymers associate with SC, they become resistant to enzymatic degradation during transcytosis.

SC and pIgR are crucial for proper mucosal immunity, acting as molecular chaperones for polymeric Igs to remain intact and enter body fluids. The human SC (pIgR) gene maps to chromosome 1q31-q41 and encodes a 764 amino acid protein containing five units homologous to immunoglobulin variable (V) regions and a transmembrane region with similar homology.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.