Thermo Fisher Scientific EDG6 Polyclonal Antibody
EDG6(S1P4) 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western Blot, IHC, ICC 등 다양한 응용에 적합. 인간과 생쥐에 반응하며 항원 친화 크로마토그래피로 정제됨. 연구용으로 사용 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 3.0–5 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-Dependent | - |
| Immunocytochemistry (ICC/IF) | 5 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A portion of amino acids 1–50 of human Sphingolipid Receptor Edg6/S1P4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term storage, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2540746 |
Target Information
EDG6 (S1P4) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG6 (S1P4) is sphingosine-1-phosphate. There are eight known members of the EDG receptor family, which are implicated in mediating growth-related effects such as induction of cellular proliferation, alterations in differentiation and survival, and suppression of apoptosis. They also evoke cellular effector functions dependent on cytoskeletal responses such as contraction, secretion, adhesion, and chemotaxis.
EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through Ras and MAP kinase, Rho, phospholipase C, and several protein tyrosine kinases.
EDG6 (S1P4) is expressed in lymphoid and hematopoietic tissue and in the lungs. The new designation for the EDG6 (S1P4) receptor is sphingosine 1-phosphate receptor-4 (S1P4).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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