Thermo Fisher Scientific TGM2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human Transglutaminase 2 (TGM2). Validated for WB, IHC(P), and ICC/IF applications. High specificity with antigen affinity purification. Provided in liquid form, 1 mg/mL concentration, for reliable research use.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2–5 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL | – |
| Immunocytochemistry (ICC/IF) | 5 µg/mL | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A portion of amino acids 600–650 of human Transglutaminase 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2540744 |
Target Information
Transglutaminase (TGase) catalyzes the crosslinking of proteins by forming ε-(γ-glutamyl) lysine isopeptide bonds and requires Ca²⁺ binding for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal β-sandwich, catalytic core, and two C-terminal β-barrel domains.
tTGase may play roles in cell death, proliferation, differentiation, and receptor-mediated endocytosis. In Alzheimer’s disease brains, elevated tTGase activity leads to polymerization of proteins such as Aβ peptide, β-amyloid precursor protein, and tau, contributing to neurofibrillary tangle formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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