Thermo Fisher Scientific Phospho-c-Kit (Tyr823) Polyclonal Antibody
Phospho-c-Kit (Tyr823)에 특이적인 Rabbit Polyclonal Antibody로, Western blot 및 Immunocytochemistry에 적합. 인간 및 조류 반응성, 항원 친화 크로마토그래피 정제. c-Kit 신호전달 연구 및 인산화 분석용 고품질 연구용 시약.
- 카탈로그번호
- 44498G
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-c-Kit (Tyr823) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 4 publications |
| Immunocytochemistry (ICC/IF) | 1:250 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Avian, Human |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Chemically synthesized phosphopeptide derived from human c-Kit region containing tyrosine 823 (sequence conserved in cow and dog) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.3, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533667 |
Target Information
KIT (c-KIT) is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT and its ligand regulate growth and activation of various hemopoietic and non-hemopoietic cells.
Mutations in KIT are associated with:
- Gastrointestinal stromal tumors
- Mast cell disease
- Acute myelogenous leukemia
- Piebaldism
Deregulation of KIT receptor TK by the activation loop mutation D816V is a focal point in therapeutic strategies against neoplastic mast cell growth.
c-Kit is expressed in hematopoietic stem cells, germ cells, mast cells, and gastrointestinal tract cajal cells. Upon binding of stem cell factor (SCF), c-kit dimerizes, leading to receptor activation and autophosphorylation of tyrosine residues, including Tyr703. This enables docking of Grb2 and activation of the Ras/ERK signaling pathway. SCF/c-kit also activates PI3K, PLC-γ, and JAK/STAT pathways, essential for hematopoiesis, stem cell maintenance, and gametogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.