Thermo Fisher Scientific Beclin 1 Polyclonal Antibody
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Beclin 1 단백질을 인식하는 Thermo Fisher Scientific의 sheep polyclonal 항체로, Western blot과 IHC에 사용 가능. 자가포식 연구에 적합하며 rat에서 검증됨. 동결건조 형태로 제공되며, 장기 보관 시 -20°C 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | 1:1,000 | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Rat |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from human Beclin-1 conjugated to blue carrier protein has been used as the antigen. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_962043 |
Product Specific Information
- Reconstitute with 150 µL of distilled water.
- Centrifuge to remove any insoluble material.
- The antigen is homologous in rat and mouse.
Target Information
Beclin 1 plays a central role in autophagy. It acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate.
Different PI3K complex forms are believed to play a role in multiple membrane trafficking pathways:
- PI3KC3-C1 is involved in the initiation of autophagosomes.
- PI3KC3-C2 is involved in the maturation of autophagosomes and endocytosis.
Beclin 1 also plays a role in antiviral host defense.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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