
Thermo Fisher Scientific Phospho-PDGFRB (Tyr579, Tyr581) Polyclonal Antibody
PDGFRB의 Tyr579 및 Tyr581 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot 및 IHC(Paraffin) 적용 가능. 고순도 액상 형태로 PBS/glycerol buffer에 보관. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PDGFRB (Accession P09619), corresponding to amino acid residues around phosphorylated Tyr579 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903159 |
Product Specific Information
Antibody detects endogenous levels of PDGF Receptor beta only when phosphorylated at Tyr579 + Tyr581.
Target Information
PDGFRB is a receptor tyrosine kinase involved in atherogenesis and cell transformation by the SIS oncogene. These growth factors act as mitogens for mesenchymal-origin cells. The receptor forms either homodimers or heterodimers depending on the bound growth factor. The PDGFRB gene is located on chromosome 5 near genes for GM-CSF and M-CSF receptor, all of which may be associated with the 5-q syndrome. A translocation between chromosomes 5 and 12 fusing PDGFRB (CD140b) and ETV6 leads to chronic myeloproliferative disorder with eosinophilia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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