Thermo Fisher Scientific Phospho-p70 S6 Kinase (Ser427) Polyclonal Antibody
Phospho-p70 S6 Kinase (Ser427)을 인식하는 Rabbit Polyclonal 항체로, 인간, 마우스, 랫트 시료에 반응합니다. Western blot, IHC, ICC/IF에 사용 가능하며, 인산화된 Ser427 부위만 선택적으로 검출합니다. 액상 형태로 제공되며 -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RPS6KB1 (Accession P23443), corresponding to amino acid residues around phosphorylated Ser427 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903157 |
Product Specific Information
This antibody detects endogenous levels of p70 S6 Kinase only when phosphorylated at Ser427.
Target Information
RPS6KB1 (p70S6K) is a serine/threonine kinase with two non-identical kinase catalytic domains that phosphorylates several residues of the S6 ribosomal protein. It is predominantly localized in the cytoplasm and plays essential roles in growth factor–regulated cell proliferation, cell motility, immune response, and tissue repair. Acting downstream of phosphoinositide (PI) 3-kinase, its main physiological target is the S6 ribosomal protein, which contributes to upregulation of protein synthesis. The kinase activity of p70 S6 kinase promotes increased protein synthesis and cell proliferation. Amplification and overexpression of p70 S6 kinase are observed in some breast cancer cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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