Thermo Fisher Scientific PDE4B Monoclonal Antibody (OTI1D12), TrueMAB
PDE4B 단백질을 인식하는 Mouse monoclonal antibody(OTI1D12)로, Western blot, IHC, ICC, Flow cytometry 등에 사용 가능. Human 및 Mouse 반응성. Lyophilized 형태로 공급되며, 재구성 시 1 mg/mL 농도 권장. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1D12 |
| Immunogen | Full length human recombinant protein of human PDE4B produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
The PDE4B gene encodes a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase family.
Cyclic nucleotides act as second messengers regulating cellular responses to extracellular stimuli such as hormones, light, and neurotransmitters.
PDEs control intracellular cAMP levels and play a central role in signal transduction.
Altered PDE4B activity has been linked to schizophrenia and bipolar affective disorder.
Multiple splice variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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