Thermo Fisher Scientific CCM2 Monoclonal Antibody (OTI1B9), TrueMAB
인간 CCM2 단백질을 인식하는 Mouse IgG1 단클론 항체로, WB 및 ICC/IF에 사용 가능. 동결건조 형태로 제공되며, PBS 및 trehalose buffer에 보관. 연구용으로 세포 신호전달 및 구조 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B9 |
| Immunogen | Full-length human recombinant CCM2 protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
CCM2 encodes a scaffold protein involved in the stress-activated p38 MAPK signaling cascade.
It interacts with SMURF1 via a phosphotyrosine-binding domain to promote RhoA degradation.
This protein is essential for maintaining cytoskeletal integrity, cell-cell interactions, and lumen formation in endothelial cells.
Mutations in CCM2 are associated with cerebral cavernous malformations.
Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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