Thermo Fisher Scientific CMIP Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.04–0.4 µg/mL
• View 1 publication

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL
• View publication

Product Specifications

Product Specific Information

Immunogen sequence:
ILKHNMDFGKC PRLRLFTQEY ILALNELNAG MEVVKKFIQS MHGPTGHCPH PRVLPNLVAV CLAAIYSCYE EFINSRDNSP SLKEIRNGCQ QPCDRKPTLP LRLLHPSPDL VSQEATLS

• Highest antigen sequence identity to the following orthologs: mouse 100%, rat 100%.

Target Information

The munc-18 interacting protein (Mint) family consists of adaptor proteins involved in membrane transport and organization.
In mammals, three isoforms exist: Mint1, Mint2, and Mint3.

• Mint1 and Mint2 are expressed exclusively in the brain and bind Munc18, a key component of synaptic vesicle fusion.
• Mint3 is ubiquitously expressed, least in brain and testis, and does not interact with Munc18.
  Mint3 interacts with the Alzheimer’s Disease-related amyloid precursor protein (APP) via PTB and PDZ domains, linking APP to transport machinery and regulating its metabolism.
  Abnormal APP metabolism is associated with early-onset Alzheimer’s disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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