Thermo Fisher Scientific CENPB Polyclonal Antibody
CENPB 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot, ICC/IF, ChIP assay에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 인간 시료에 반응합니다. PBS 기반 용액으로 장기 보관 시 -20°C에서 안정하게 유지됩니다.
- 카탈로그번호
- PA565869
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
| ChIP assay (ChIP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human CENPB. Recombinant protein control fragment (Product #RP-106539) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2662433 |
Product Specific Information
Immunogen sequence:
TFREKSRIIQE VEENPDLRKG EIARRFNIPP STLSTILKNK RAILASERKY GVASTCRKTN KLSPYDKLEG LLIAWFQQIR AAGLPVKGII L
Highest antigen sequence identity to the following orthologs:
- Mouse: 100%
- Rat: 100%
Target Information
CENPB is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein derived from transposases of the pogo DNA transposon family.
It contains a helix-loop-helix DNA-binding motif at the N-terminus and a dimerization domain at the C-terminus.
The DNA-binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA.
CENPB plays an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes and is considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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