Thermo Fisher Scientific CaMKIV Polyclonal Antibody
CaMKIV 단백질을 검출하는 Thermo Fisher Scientific의 rabbit polyclonal antibody. Western blot 및 IHC에 적합하며 다양한 종에 반응. 항원 친화 크로마토그래피로 정제된 고품질 항체로 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | View 2 publications |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:100 | - |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | - |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Non-human primate, Plant, Rat, Xenopus |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic Peptide: V(127)EKGYYSERDAADAVKQ(143)C |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_325834 |
Product Specific Information
PA1-542 detects CaM kinase IV (CaMKIV) from human, mouse, rat, canine, primate, arabidopsis, and Xenopus oocyte samples.
It has been successfully used in Western blot and immunohistochemistry procedures.
By Western blot, this antibody detects an ~55 kDa protein representing CaMKIV in HeLa cell lysate.
The immunizing peptide corresponds to amino acid residues 127–143 from mouse CaMKIV.
This sequence is 94% conserved in rat and human CaMKIV.
This peptide (Cat. PEP-109) is available for use in neutralization and control experiments.
Target Information
CAMK4 (CaMKIV) is a serine/threonine protein kinase that phosphorylates CREB, oncoprotein 18, and SRF.
It has limited tissue distribution and is implicated in transcriptional regulation in lymphocytes, neurons, and male germ cells.
CaMKIV is abundant in testis, T-cells, and neurons, but also found in other tissues to varying degrees.
In neurons, it plays an important role in synaptic plasticity via gene regulatory effects.
In T-cells, CaMKIV is involved in calcium signaling affecting nuclear factor of activated T-cells (NFAT).
CaMKIV is encoded along with calspermin by the CaMKIV gene and is associated with chromatin in germ cells, suggesting a role in chromatin remodeling during nuclear condensation in spermatids.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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