Thermo Fisher Scientific CaMKIV Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

PA1-542 detects CaM kinase IV (CaMKIV) from human, mouse, rat, canine, primate, arabidopsis, and Xenopus oocyte samples.
It has been successfully used in Western blot and immunohistochemistry procedures.
By Western blot, this antibody detects an ~55 kDa protein representing CaMKIV in HeLa cell lysate.

The immunizing peptide corresponds to amino acid residues 127–143 from mouse CaMKIV.
This sequence is 94% conserved in rat and human CaMKIV.
This peptide (Cat. PEP-109) is available for use in neutralization and control experiments.

Target Information

CAMK4 (CaMKIV) is a serine/threonine protein kinase that phosphorylates CREB, oncoprotein 18, and SRF.
It has limited tissue distribution and is implicated in transcriptional regulation in lymphocytes, neurons, and male germ cells.
CaMKIV is abundant in testis, T-cells, and neurons, but also found in other tissues to varying degrees.
In neurons, it plays an important role in synaptic plasticity via gene regulatory effects.
In T-cells, CaMKIV is involved in calcium signaling affecting nuclear factor of activated T-cells (NFAT).
CaMKIV is encoded along with calspermin by the CaMKIV gene and is associated with chromatin in germ cells, suggesting a role in chromatin remodeling during nuclear condensation in spermatids.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지