Thermo Fisher Scientific KCNQ1 Polyclonal Antibody
KCNQ1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, IHC, ICC, ELISA 등 다양한 응용에 적합. 인간, 마우스, 랫트, 개 시료에 반응하며, Protein A로 정제된 고순도 항체. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human KCNQ1 (amino acids 501–600) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS (pH 7.4), 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Voltage-gated K⁺ channels in the plasma membrane control repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells.
KCNQ1, together with KCNE1, forms a channel complex predominantly expressed in the heart and cochlea, regulating the slow depolarization-activated potassium current.
Mutations in KCNQ1 and KCNE1 are associated with cardiac diseases due to impaired electrical signaling, while KCNQ4 mutations are linked to deafness.
KCNQ proteins typically contain six transmembrane domains and function as tetramers. KCNQ4 can form heteromeric channels with KCNQ3 and is expressed in several tissues, including the cochlea.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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