Thermo Fisher Scientific MSR1 Polyclonal Antibody
MSR1/CD204 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC, Flow, ELISA 등 다양한 응용 가능. Protein A로 정제된 1 mg/mL 액상 시약이며, 인간, 마우스, 양, 랫트에 반응. 연구용으로만 사용.
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Thermo Fisher Scientific MSR1 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Sheep, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human MSR1/CD204 (amino acids 211–320) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD204 gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing. These receptors are macrophage-specific trimeric integral membrane glycoproteins involved in various physiological and pathological processes such as atherosclerosis, Alzheimer’s disease, and host defense.
Isoforms type 1 and 2 mediate endocytosis of modified low density lipoproteins (LDLs), while isoform type 3 does not internalize modified LDL due to altered intracellular processing and retention in the endoplasmic reticulum. Type 3 can inhibit the function of types 1 and 2 through a dominant negative effect, regulating scavenger receptor activity in macrophages.
Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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