Thermo Fisher Scientific Human MC4R Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 19 amino acids near the amino terminus of human MC4R.
PEP-0873 can be used as a blocking peptide with polyclonal antibody PA5-20759.

Target Information

Expression of MC4R has been reported in brain. Unlike the other melanocortin receptors, MC4R is not expressed in adrenal cortex or in melanocytes.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist.
All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms.
An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors.
Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs.
This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates.
Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough), which have multi-billion dollar shares of the mental health and allergy markets, respectively.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.