Thermo Fisher Scientific Human SHOC2 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 21 amino acids near the amino terminus of human SHOC2.
PEP-0876 can be used as a blocking peptide with polyclonal antibody PA5-20762.

Target Information

SHOC2 protein participates in protein binding and transferase activity within the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction. It is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and localized in the cytoplasm.

SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade, which is elicited by EGL-15 and LET-23 and mediated by LET-60. SHOC2, together with protein phosphatase 1c (PP1c), forms a highly specific M-Ras effector complex and is essential for activation of the MAPK pathway by growth factors.

In tumor cells with Ras gene mutations, inhibition of SHOC2 expression suppresses MAPK activity but not PI3K activity. The SHOC2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer.

Recent studies show that aberrantly acquired N-myristoylation of SHOC2 causes human disease Noonan-like syndrome with loose anagen hair.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.