Thermo Fisher Scientific p53 (Tumor Suppressor Protein) Recombinant Rabbit Monoclonal Antibody (TP53/7002R)

Applications and Tested Dilution

Product Specifications

Target Information

The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nutrient deprivation. Upon activation, p53 stimulates transcription of genes such as p21waf1, leading to G1 or G2/M arrest.

Structurally, p53 includes an N-terminal transactivation domain, a central DNA-binding domain, an oligomerisation domain, and a C-terminal regulatory domain. Phosphorylation at Ser15 is crucial for activation and stabilization, while phosphorylation at Ser392 is associated with tumor formation.

p53 plays a key role in preventing proliferation of damaged cells and acts as an anticancer factor. It is also linked to aging, oxidative stress, and cognitive functions such as learning and memory. While expressed at low levels in normal cells, p53 is highly expressed in many transformed cell lines, contributing to malignancy. Mutations in the TP53 gene can result in loss of tumor suppressor activity and are common in various human cancers, including hereditary conditions such as Li-Fraumeni syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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