Thermo Fisher Scientific p53 (Tumor Suppressor Protein) Recombinant Rabbit Monoclonal Antibody (TP53/3890R)

Thermo Fisher Scientific p53 (Tumor Suppressor Protein) Recombinant Rabbit Monoclonal Antibody (TP53/3890R)

Applications and Tested Dilution

Product Specifications

Target Information

The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nutrient deprivation. p53 activation leads to transcription of genes such as p21waf1, regulating G1 or G2/M arrest. Structurally, p53 includes an N-terminal transactivation domain, a central DNA-binding domain, an oligomerization domain, and a C-terminal regulatory domain.

Phosphorylation at Ser15 is crucial for activation and stabilization, while Ser392 phosphorylation is associated with tumor formation. p53 plays a key role in preventing proliferation of damaged cells, acting as an anticancer agent. It is typically found at low levels in normal cells but highly expressed in transformed cell lines. Mutations in p53 disrupt DNA binding and tumor suppressor function, contributing to malignancy. Germline TP53 mutations are linked to cancer-prone syndromes such as Li-Fraumeni.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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