Thermo Fisher Scientific RORC Monoclonal Antibody (OTI3C9), TrueMAB
RORC 단백질을 인식하는 Mouse IgG1 단일클론 항체로 Western blot에 적합. Human, Mouse, Rat 반응성 확인. 동결건조 형태로 보존 용이하며, 재구성 후 1 mg/mL 농도 유지. 연구용으로 ROR gamma 관련 면역 및 전사 조절 연구에 활용 가능.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3C9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–266 of human RORC produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
ROR gamma is a 560 amino acid DNA-binding transcription factor belonging to the ROR/RZR orphan nuclear receptor subfamily.
It acts as a ligand-activated transcription factor and plays a crucial role in lymphoid organogenesis (lymph nodes and Peyer’s patches) and apoptosis regulation during thymopoiesis.
ROR gamma inhibits Fas ligand and IL2 expression and directs the differentiation of proinflammatory IL-17+ T helper cells.
It shares 50–51% sequence identity with RORA and RORB and is 88% identical to mouse ROR gamma.
Highly expressed in skeletal muscle, with lower levels in various other tissues.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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