Thermo Fisher Scientific GUCY1B2 Polyclonal Antibody
Thermo Fisher Scientific의 GUCY1B2 Polyclonal Antibody는 인간, 마우스, 랫트 시료에서 GCS beta 2 단백질을 검출하는 고품질 항체입니다. Western Blot, IHC, ICC/IF에 사용 가능하며, 고순도 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GUCY1B2 (Accession O75343), corresponding to amino acid residues P581–L617 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852505 |
Product Specific Information
Antibody detects endogenous levels of total GCS beta 2.
Target Information
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase:
- Soluble form (GCS or sGC): Acts as a receptor for nitric oxide (NO).
- Membrane-bound form (GC): Functions as peptide hormone receptors.
GCS is a cGMP-synthesizing enzyme and the major receptor for NO, playing a crucial role in smooth muscle contractility, platelet reactivity, and neurotransmission. It is a heme-containing heterodimer composed of one 72 kDa alpha subunit and one 65 kDa beta subunit. The heme moiety mediates NO activation and can also bind carbon monoxide, which weakly stimulates the enzyme.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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