Thermo Fisher Scientific WWTR1 Monoclonal Antibody (OTI1H9), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).

Target Information

WW domain-containing transcription regulator protein 1 (WWTR1) is a transcriptional coactivator acting as a downstream regulatory target in the Hippo signaling pathway, which controls organ size and tumor suppression by restricting proliferation and promoting apoptosis.
This pathway involves a kinase cascade where STK3/MST2 and STK4/MST1, together with SAV1, activate LATS1/2 in complex with MOB1. MOB1 then phosphorylates and inactivates YAP1 and WWTR1/TAZ.
WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation, regulates nuclear accumulation of SMADS, and couples them to transcriptional machinery such as the mediator complex.
It also plays a role in embryonic stem-cell self-renewal, cell proliferation, and epithelial-mesenchymal transition.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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