Thermo Fisher Scientific LEMD2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1–2 µg/mL

Immunocytochemistry (ICC/IF)

• Tested Dilution: 2.5 µg/mL

Product Specifications

Product Specific Information

• A suggested positive control is 293 cell lysate.
• PA5-34397 can be used with blocking peptide PEP-1439.

Target Information

The LEM (lamina-associated polypeptide-emerin-MAN1) domain is a motif shared by lamin-interacting proteins of the inner nuclear membrane (INM) and nucleoplasm.
LEMD2 (LEM domain-containing protein 2) is a lamina-associated protein in the INM involved in nuclear structure organization. It contains an N-terminal LEM motif, two transmembrane domains, and a MAN1-Src1p C-terminal (MSC) domain.
LEMD2 is a truncated paralog of MAN1, lacking the MAN1-specific C-terminal RNA-recognition motif, but like MAN1, it is required for myogenic differentiation.
Mutations in LEMD2 are thought to be among possible causes of muscle disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.