Thermo Fisher Scientific SHH Polyclonal Antibody
SHH 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 ELISA에 적합. Human과 Mouse에 반응하며, 항원 친화 크로마토그래피로 정제됨. 액상 형태로 4°C~−20°C 보관 가능. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1 µg/mL
ELISA
- Tested Dilution: 0.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide conjugated to KLH derived from within residues 1–100 of Human Sonic Hedgehog |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.7 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at −20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10983006 |
Product Specific Information
- Not suitable for use with Immunohistochemistry - Free Floating.
- Predicted to react with rat, chicken, cow, human, Xenopus laevis, zebrafish and many other species based on sequence homology.
Target Information
Sonic Hedgehog (SHH) is expressed only during embryogenesis and plays a crucial role in early embryonic patterning. It is a key inductive signal in the formation of the ventral neural tube, anterior-posterior limb axis, and ventral somites. The SHH precursor undergoes autocatalytic cleavage, generating an N-terminal signaling domain and a C-terminal processing domain. The C-terminal product attaches a cholesterol moiety to the N-terminal product, restricting its diffusion. Defects in SHH or its signaling pathway can cause holoprosencephaly (HPE), characterized by abnormal forebrain development and facial deformities, and may also be linked to VACTERL syndrome involving multiple congenital anomalies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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