Thermo Fisher Scientific F13A1 Monoclonal Antibody (OTI8E2), Biotin, TrueMAB

Applications

ELISA (ELISA)

• Tested Dilution: 1:250–1:1,000

Luminex (LUM)

• Tested Dilution: Assay-dependent

Product Specifications

Additional Formats

• Unconjugated
• Request custom conjugation

Target Information

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the final zymogen activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of two A subunits and two B subunits. The A subunits have catalytic function, while the B subunits act as plasma carriers. Platelet factor XIII consists only of two A subunits identical to those in plasma. Upon thrombin cleavage and in the presence of calcium ions, plasma factor XIII dissociates its B subunits and yields the active enzyme factor XIIIa, which functions as a transglutaminase, stabilizing fibrin clots by crosslinking fibrin molecules and other proteins such as α2-plasmin inhibitor and fibronectin. Deficiency in factor XIII can cause bleeding disorders, impaired wound healing, and habitual abortion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.