Thermo Fisher Scientific F13A1 Monoclonal Antibody (OTI3E3), Biotin, TrueMAB

Applications

ELISA (ELISA)

• Tested Dilution: 1:250–1:1,000

Luminex (LUM)

• Tested Dilution: Assay-dependent

Product Specifications

Additional Formats

• Unconjugated
• Request custom conjugation

Target Information

This gene encodes the coagulation factor XIII A subunit, the final zymogen activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer of two A subunits and two B subunits. The A subunits have catalytic activity, while the B subunits act as carrier molecules. Platelet factor XIII contains only two A subunits, identical to plasma A subunits. Upon thrombin cleavage and in the presence of calcium, plasma factor XIII dissociates its B subunits to yield the active enzyme factor XIIIa, a transglutaminase that crosslinks fibrin molecules to stabilize the clot. It also links alpha-2-plasmin inhibitor or fibronectin to fibrin alpha chains. Deficiency in factor XIII can lead to bleeding disorders, impaired wound healing, and recurrent miscarriage.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.