Thermo Fisher Scientific F13A1 Monoclonal Antibody (OTI4D2), Biotin, TrueMAB

Thermo Fisher Scientific F13A1 Monoclonal Antibody (OTI4D2), Biotin, TrueMAB

Applications and Tested Dilution

• ELISA (ELISA): 1:250–1:1,000
• Luminex (LUM): Assay-dependent

Product Specifications

Additional Formats

• Unconjugated
• Request custom conjugation

Target Information

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of two A subunits and two B subunits. The A subunits have catalytic function, while the B subunits serve as plasma carrier molecules. Platelet factor XIII consists only of two A subunits, identical to those of plasma origin. Upon activation by thrombin and calcium ions, plasma factor XIII dissociates its B subunits and yields the active enzyme factor XIIIa, identical to platelet factor XIII. This enzyme acts as a transglutaminase to catalyze gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, stabilizing the clot. It also crosslinks alpha-2-plasmin inhibitor or fibronectin to fibrin alpha chains. Factor XIII deficiency is classified into type I (lack of both A and B subunits) and type II (lack of A subunit only), resulting in bleeding tendency, defective wound healing, and habitual abortion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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