Thermo Fisher Scientific PDE8A Polyclonal Antibody
PDE8A 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. Western blot, IHC, IP 등 다양한 분석에 사용 가능. Rabbit IgG 기반으로 제작되었으며 액상 형태로 제공. 장기 보관 시 -20°C에서 보관 권장.
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Thermo Fisher Scientific PDE8A Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunoprecipitation (IP) | 1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic cyclic peptide from near the N terminus (common to all PDE8A variants) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.75 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2161741 |
Product Specific Information
PA1-31141 detects PDE8A from human, rat, and mouse samples.
Target Information
Phosphodiesterases (PDEs) regulate the intracellular levels of cAMP and cGMP. These cyclic nucleotides act as second messengers in multiple physiological processes, including regulation of vascular resistance, cardiac output, visceral motility, immune response, inflammation, neuroplasticity, vision, and reproduction.
PDEs comprise a large superfamily of enzymes divided into 10 families, distinguished by structure, tissue expression, localization, substrate specificity, regulation, and sensitivity to PDE inhibitors.
Due to their structural diversity and functional specificity, PDEs are promising targets for pharmacotherapy of diseases modulated by cyclic nucleotide signaling (Hetman et al., 2000).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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