Thermo Fisher Scientific TRPC6 Polyclonal Antibody
Zebrafish TRPC6 단백질을 표적으로 하는 Rabbit Polyclonal Antibody. Western blot 및 IHC에 사용 가능. 동결건조 형태로 제공되며 장기 보관 시 -20°C에서 안정적. 연구용으로만 사용.
- 카탈로그번호
- OST00081W-100UL
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific TRPC6 Polyclonal Antibody
Applications
- Western Blot (WB): 1:300–1:2,000
- Immunohistochemistry (IHC): 1:300–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Zebrafish |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from zebrafish TRPC6 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: TRPC6.
Target Information
TRPC6 forms a receptor-activated calcium channel in the cell membrane. The TRPC6 channel is activated by diacylglycerol (DAG) and is regulated by the phosphatidylinositol second messenger system. Activation occurs independently of protein kinase C and is not triggered by low intracellular calcium levels.
Defects in the TRPC6 gene are associated with focal segmental glomerulosclerosis 2 (FSGS2). TRPC6 belongs to the mammalian transient receptor potential (TRP) superfamily, specifically the “canonical TRP” (TRPC) family. Members of this family are activated through PLC-coupled receptors and act as receptor-regulated cation channels.
TRPC6/6/7 subfamily members can be activated by DAG analogs, suggesting a mechanism of activation via PLC-coupled receptors. When expressed in transfected cells, TRPC6 functions as a non-selective, store-independent receptor-activated cation channel. It is activated by DAG in a PKC-independent manner and is insensitive to IP3 activation. Increasing evidence indicates that TRPC6 encodes endogenous DAG-activated receptor-operated cation channels in vivo.
Diseases associated with TRPC6 include focal segmental glomerulosclerosis (FSGS2).
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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