Thermo Fisher Scientific TRPC6 Polyclonal Antibody
Zebrafish TRPC6 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC에 사용 가능. Lyophilized 형태로 제공되며, PBS buffer에 보존. 장기 보관 시 -20°C에서 안정적이며, TRPC6 관련 연구에 적합.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 10–50 µg/mL
Immunohistochemistry (IHC)
- Tested Dilution: 10–50 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Zebrafish |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide as a part of zebrafish TRPC6 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: TRPC6.
Target Information
Trpc6 forms a receptor-activated calcium channel in the cell membrane. The Trpc6 channel is activated by diacylglycerol (DAG) and is controlled by a phosphatidylinositol second messenger system. Activation occurs independently of protein kinase C and is not triggered by low intracellular calcium levels.
Defects in the Trpc6 gene cause focal segmental glomerulosclerosis 2 (FSGS2). Trpc6 belongs to the mammalian transient receptor potential (TRP) superfamily, specifically the “canonical TRP” (TRPC) family. Members of this family are components of receptor-regulated cation channels and are activated through PLC-coupled receptors.
The TRPC6/6/7 subfamily can be activated by DAG analogs, suggesting a mechanism of activation by PLC-coupled receptors. When expressed in transfected cells, Trpc6 acts as a non-selective, store-independent, receptor-activated cation channel. It is activated by DAG in a PKC-independent manner and is insensitive to IP3 activation. Evidence indicates that Trpc6 encodes endogenous DAG-activated receptor-operated cation channels in vivo.
Diseases associated with TRPC6 include:
- Glomerulosclerosis, Focal Segmental, 2
- Focal Segmental Glomerulosclerosis
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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