Thermo Fisher Scientific Angiotensinogen Recombinant Rabbit Monoclonal Antibody (034)
Human SerpinA8/Angiotensinogen/AGT에 특이적인 재조합 토끼 단클론 항체로 높은 특이성과 민감도를 제공. WB, IHC, ICC 등 다양한 응용에 적합. 보존제가 없는 액상 형태로 제공되며, 장기 보관 시 -20°C 권장. 로트 간 일관성 및 동물 유래 성분 무첨가.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 | - |
| Immunocytochemistry (ICC/IF) | 1:200 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 034 |
| Immunogen | Recombinant Human SerpinA8/Angiotensinogen/AGT protein (Met1–Ala485) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2784948 |
Product Specific Information
This product is preservative free. It is recommended to add sodium azide (final concentration 0.05%–0.1%) to prevent contamination.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal production candidates.
Advantages of recombinant rabbit monoclonal antibodies:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to larger rabbit immune repertoire
This antibody has specificity for Human SerpinA8/Angiotensinogen/AGT.
Target Information
The AGT gene encodes pre-angiotensinogen (angiotensinogen precursor), expressed primarily in the liver. It is cleaved by renin in response to low blood pressure to form angiotensin I, which is further converted by ACE to angiotensin II, an active enzyme that regulates blood pressure.
The protein plays a role in maintaining blood pressure and is implicated in essential hypertension and preeclampsia. Mutations in AGT are associated with susceptibility to hypertension, renal tubular dysgenesis, atrial fibrillation, and inflammatory bowel disease.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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