Thermo Fisher Scientific Phospho-PFKFB2 (Ser466) Polyclonal Antibody
인산화된 Ser466 위치의 PFKFB2 단백질을 특이적으로 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC 등 다양한 응용에 적합하며, 높은 특이성과 재현성을 제공. 연구용으로만 사용 가능.
- 카탈로그번호
- PA5106066
- 판매단위
- pk
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Thermo Fisher Scientific Phospho-PFKFB2 (Ser466) Polyclonal Antibody
Applications and Tested Dilutions
- Western Blot (WB): 1:1,000–1:3,000
- Immunohistochemistry (Paraffin) (IHC-P): 1:50–1:200
- Immunocytochemistry (ICC/IF): 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PFKFB2 (Accession O60825), corresponding to amino acid residues around phosphorylated Ser466 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS (pH 7.4) with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817465 |
Product Specific Information
This antibody detects endogenous levels of PFKFB2 only when phosphorylated at Ser466.
Target Information
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the γ phosphate of ATP, onto an acceptor amino acid in a substrate protein. Through this mechanism, protein kinases mediate most signal transduction in eukaryotic cells, regulating metabolism, transcription, cell cycle progression, cytoskeletal rearrangement, cell movement, apoptosis, and differentiation.
The protein kinase family includes over 500 gene products and is classified into 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.
The AGC kinase group consists of 63 kinases, including:
- Cyclic nucleotide-regulated protein kinase (PKA & PKG) family
- Diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family
- Related to PKA and PKC (RAC/Akt) protein kinase family
- Kinases that phosphorylate G protein-coupled receptors (ARK)
- Kinases that phosphorylate ribosomal protein S6 (RSK)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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