Thermo Fisher Scientific CD279 (PD-1) Monoclonal Antibody (EH12.2H7), FITC

Applications

• Flow Cytometry (Flow): 4 µL/10^6 cells

Product Specifications

Additional Formats

• Unconjugated (MA5-28584)
• APC (MA5-38701)
• PE (MA5-28583)
• Custom conjugation available upon request

Product Specific Information

This antibody recognizes an extracellular epitope of CD279 / PD-1 (programmed cell death 1), a 55 kDa type I transmembrane protein expressed primarily during T cell development, and on activated T cells, B cells, and monocytes.

Target Information

Cell-mediated immune responses are initiated by T lymphocytes stimulated by peptides bound to MHC molecules on antigen-presenting cells (APC). Activated T cells express inhibitory receptors such as PD-1 (PDCD-1), which modulate immune activation by binding ligands PDL-1 and PDL-2. These interactions inhibit immune responses in the absence of danger signals such as LPS. PD-1 deficiency results in hyperactivated immune systems and autoimmune phenotypes. Although PD-1 has a predicted molecular weight of 55 kDa, it often migrates at a higher molecular weight in SDS-PAGE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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