Thermo Fisher Scientific CD107b (LAMP-2) Monoclonal Antibody (H4B4), APC

Applications

• Flow Cytometry (Flow): 10 µL/10⁶ cells

Product Specifications

Additional Formats

• Unconjugated (Cat. No. MA5-28577)
• Alexa Fluor 488 (Cat. No. MA5-18122)
• Custom conjugation available upon request

Product Specific Information

This antibody recognizes an extracellular/luminal epitope of CD107b (LAMP-2), an extensively glycosylated 100–120 kDa lysosome-associated protein widely expressed in human cells.

Target Information

LAMP2 (Lysosome-associated membrane glycoprotein 2, CD107b) is a member of the lysosomal membrane glycoprotein family. It provides selectins with carbohydrate ligands and may play roles in tumor cell metastasis, lysosomal protection, maintenance, and adhesion.

Prior to modification, LAMP2 is a 46 kDa polypeptide. The mature form is heavily glycosylated (100–130 kDa) and consists of:

• A large intra-lysosomal amino-terminal domain
• A hydrophobic transmembrane domain
• A short cytoplasmic tail

LAMP2 is used as a marker for chaperone-mediated autophagy. It has three isoforms (LAMP-2A, LAMP-2B, LAMP-2C) and, along with CD107a/LAMP-1, constitutes a major component of the lysosomal membrane. These proteins are essential for lysosome biogenesis and fusion with phagosomes. LAMP2 deficiency causes accumulation of autophagosomes, leading to cardiomyopathy and myopathy (Danon’s disease).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지