Thermo Fisher Scientific CD107b (LAMP-2) Monoclonal Antibody (H4B4), APC
CD107b (LAMP-2) 단백질을 인식하는 APC 결합 단클론 항체. 인간 시료에 반응하며, Flow Cytometry에 적합. 세포 내 리소좀 관련 단백질 연구 및 오토파지 모니터링에 유용. 4°C 보관, 동결 금지.
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Applications
- Flow Cytometry (Flow): 10 µL/10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | H4B4 |
| Immunogen | Human PBMC |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898615 |
Additional Formats
- Unconjugated (Cat. No. MA5-28577)
- Alexa Fluor 488 (Cat. No. MA5-18122)
- Custom conjugation available upon request
Product Specific Information
This antibody recognizes an extracellular/luminal epitope of CD107b (LAMP-2), an extensively glycosylated 100–120 kDa lysosome-associated protein widely expressed in human cells.
Target Information
LAMP2 (Lysosome-associated membrane glycoprotein 2, CD107b) is a member of the lysosomal membrane glycoprotein family. It provides selectins with carbohydrate ligands and may play roles in tumor cell metastasis, lysosomal protection, maintenance, and adhesion.
Prior to modification, LAMP2 is a 46 kDa polypeptide. The mature form is heavily glycosylated (100–130 kDa) and consists of:
- A large intra-lysosomal amino-terminal domain
- A hydrophobic transmembrane domain
- A short cytoplasmic tail
LAMP2 is used as a marker for chaperone-mediated autophagy. It has three isoforms (LAMP-2A, LAMP-2B, LAMP-2C) and, along with CD107a/LAMP-1, constitutes a major component of the lysosomal membrane. These proteins are essential for lysosome biogenesis and fusion with phagosomes. LAMP2 deficiency causes accumulation of autophagosomes, leading to cardiomyopathy and myopathy (Danon’s disease).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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