Thermo Fisher Scientific Propoxyphene Polyclonal Antibody

Applications

• ELISA (ELISA)
  Tested Dilution: 5–10 µg/mL

Product Specifications

Product Specific Information

• PA1-75369 specifically detects Propoxyphene.
• PA1-75369 has been successfully used in ELISA applications.
• The PA1-75369 immunogen is Propoxyphene-BSA.

Target Information

Propoxyphene is the d-isomer of synthetic diphenyl propionate derivative propoxyphene, with narcotic analgesic effect. This agent mimics the effects of the endogenous opiate dextropropoxyphene by binding to mu receptors located throughout the central nervous system. The binding results in GTP to GDP exchanges on the mu-G-protein complex, by which effector adenylate cyclase is inactivated, thereby decreasing intracellular cAMP. This inhibits the release of various nociceptive neurotransmitters such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, noradrenaline, vasopressin, and somatostatin. In addition, dextropropoxyphene closes N-type voltage-gated calcium channels and opens calcium-dependent inwardly rectifying potassium channels. This results in hyperpolarization, thereby reducing neuronal excitability, which further decreases the perception of pain.
[National Center for Biotechnology Information. PubChem Compound Database; CID=10100]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.