Thermo Fisher Scientific CCL5 (RANTES) Polyclonal Antibody

Applications

ELISA (ELISA)

• Tested Dilution: 5–10 µg/mL

Product Specifications

Product Specific Information

• PA1-75377 specifically detects CCL5 (RANTES).
• Validated for use in ELISA applications.
• Immunogen: Recombinant RANTES.

Target Information

CCL5 (RANTES) is a chemokine gene located on the q-arm of chromosome 17.
Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes.
The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide.

CCL5, a member of the CC subfamily:

• Functions as a chemoattractant for blood monocytes, memory T helper cells, and eosinophils
• Induces histamine release from basophils and activates eosinophils
• Acts as a major HIV-suppressive factor produced by CD8+ cells
• Serves as a natural ligand for CCR5, suppressing replication of R5 strains of HIV-1
• Undergoes alternative splicing, producing multiple transcript variants

Diseases associated with CCL5 include Human Immunodeficiency Virus Type 1 and Periapical Granuloma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.