Thermo Fisher Scientific HYAL2 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:300

Product Specifications

Product Specific Information

The antibody detects endogenous levels of total HYAL2 protein.

Target Information

This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration, and differentiation. Although it was previously thought to be a lysosomal hyaluronidase active at pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. It encodes two alternatively spliced transcript variants differing only in the 5′ UTR.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.