Thermo Fisher Scientific HAVCR2 Monoclonal Antibody (OTI2E5), TrueMAB
HAVCR2(TIM-3) 단백질을 인식하는 Mouse IgG2b 단일클론 항체로, WB 및 Flow Cytometry에 최적화됨. HEK293T에서 생산된 full-length human recombinant protein을 면역원으로 사용. 무보존제, 동결건조 형태로 제공되며 재구성 및 결합 실험에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Flow Cytometry (Flow)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2E5 |
| Immunogen | Full length human recombinant protein of human HAVCR2 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-domain containing-3) is a 281 amino acid, Type-1 Th1-specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells.
It consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved tyrosine phosphorylation motif in the cytoplasmic region.
TIM3 plays a role in macrophage activation and autoimmune disease induction, down-regulates Th1-mediated immune responses, and contributes to immune tolerance.
Pathological significance has been noted in experimental autoimmune encephalomyelitis (EAE), a Th1-dependent autoimmune disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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