Thermo Fisher Scientific HAVCR2 Monoclonal Antibody (OTI1C4), TrueMAB
인간 HAVCR2(TIM-3)을 표적으로 하는 Mouse IgG1 단클론 항체로, Western blot 및 유세포분석에 적합합니다. 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도로 사용 가능합니다. 면역 관용 및 자가면역 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Flow Cytometry (Flow)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1C4 |
| Immunogen | Full length human recombinant protein of human HAVCR2 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
- For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-domain containing-3) is a 281 amino acid, Type-1 Th1-specific cell surface glycoprotein expressed on terminally differentiated CD4+ Th1 and CD8+ Tc1 cells.
It includes an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved tyrosine phosphorylation motif in the cytoplasmic region.
TIM3 participates in macrophage activation and autoimmune disease induction, down-regulating Th1-mediated immune responses and promoting immune tolerance.
Its pathological significance is linked to experimental autoimmune encephalomyelitis (EAE), a Th1-dependent autoimmune disease that increases EAE severity in mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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