Thermo Fisher Scientific ESRRB Polyclonal Antibody
Rabbit polyclonal antibody targeting human ESRRB, validated for IHC(P) at 1 µg/mL. Recognizes multiple species with high sequence identity. Supports research on stem cell pluripotency and differentiation. Supplied as liquid, 1 mg/mL, purified by antige...
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Applications
- Immunohistochemistry (Paraffin) [IHC (P)]: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Horse, Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 16 amino acid peptide from N-terminus of human ESRRB |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550903 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human, Gorilla, Monkey, Marmoset, Horse: 100%
- Mouse, Rat, Elephant, Panda: 94%
- Dog, Pig: 88%
- Bat, Bovine, Rabbit: 81%
Target Information
ESRRB (steroid hormone receptor ERR2) plays a role in maintaining self-renewal and pluripotency of embryonic and trophoblast stem cells through signaling pathways such as FGF and Wnt.
Upon FGF pathway activation, ESRRB interacts with KDM1A, binding to enhancer sites of ELF5 and EOMES, activating transcription and promoting trophoblast stem cell self-renewal.
ESRRB also regulates rod-specific gene expression and is required for survival of this cell type.
Defects in ESRRB can cause autosomal recessive deafness (DFNB35).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-33523_ESRRB_O95718-3_Rabbit.svg, PA5-33523_ESRRB_O95718-3_Rabbit_PDP.jpeg)
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