Thermo Fisher Scientific Podoplanin Polyclonal Antibody, FITC
FITC로 결합된 Podoplanin 폴리클로날 항체로 인간, 마우스, 비인간 영장류에 반응합니다. Western blot, IHC, ELISA, IP 등 다양한 응용에 사용 가능하며, 높은 특이성과 안정성을 제공합니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- PDPN-N-FITC
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Podoplanin Polyclonal Antibody, FITC
Thermo Fisher Scientific Podoplanin Polyclonal Antibody, FITC
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 30–100 on human Podoplanin protein |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin-type 1 glycoprotein with a molecular weight of 40–43 kDa. It is expressed in various tumors and normal cells, particularly lymphatic epithelial cells and follicular dendritic cells. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of lymphatic endothelium, it plays a role in maintaining the unique morphology of podocytes. Podoplanin serves as a ligand for CLEC-2, and its expression correlates with tumor invasiveness and metastatic potential. It is directly involved in cell migration, metastasis formation, and tumor invasion. Podoplanin expression is induced through Src activation of Cas and may also be present on Th17 cells. Studies suggest its presence on a small population of CD4+ cells from human PBMC. Dysfunction of podoplanin has been linked to diseases such as lymphangioma and subglottis neoplasm. It has also been proposed as a marker for lung injury due to its physiological function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.