Thermo Fisher Scientific Phospho-HDAC5 (Ser498) Polyclonal Antibody
인간, 마우스, 랫트 시료에 반응하는 Rabbit Polyclonal 항체로 Ser498 부위의 인산화된 HDAC5를 검출. Western blot과 ELISA에 적합하며, 고순도 친화 크로마토그래피 정제 제품. 세포 신호전달 및 전사 조절 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphorylated peptide around S498 of human HDAC5 (NP_0054652) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901813 |
Product Specific Information
- Positive Samples: NIH/3T3, NIH/3T3 + Insulin
- Immunogen Sequence: TQSSP
Target Information
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events.
Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA.
The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family.
It possesses histone deacetylase activity and represses transcription when tethered to a promoter.
It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins.
It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes.
This gene is thought to be associated with colon cancer.
Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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